Topic: APPNL-G-F

Among the three ApoE isoforms, ApoE4 is a major risk factor for sporadic AD due to its impact on amyloid beta (Abeta) clearance and plaque formation. Although extensive research has connected ApoE to various AD-related pathologies beyond Abeta, its association with ApoE isoforms remains an area that requires further investigation. This study aimed to elucidate the effects of ApoE isoforms on AD pathology using human ApoE Knock-In (KI) AD mouse models. First, we generated an APPNL-G-F;hApoE (ApoE Double KI) mouse model by crossing human ApoE3 or ApoE4 KI mice with APPNL-G-F KI mice. Additionall

Atypical astrocytes (AtAs) are a distinct subset of non-reactive astrocytes in the brain characterized by dramatically diminished expression of excitatory amino acid transporters (GLAST, GLT1) and other astrocytic proteins. Our ongoing research on the development and progression of AtAs in naïve wild type (WT) mice has shown significant regional and age effects. We have also shown that brain tissue from confirmed Alzheimer’s Disease (AD) patients, as well as healthy controls, have areas of presumptive AtAs. This study aims to further explore the role of AtAs in AD pathology utilizing the APPNL