Topic: atorvastatin

Our study investigates the potential synergistic effect of regenerative therapy combining electrical stimulation with application of anti-inflammatory drug atorvastatin (ATR) following spinal cord injury (SCI). Using an isoflurane anesthesia, we induced SCI at the T9 segment with a compression device for 15 minutes under a 40g weight. An oscillating field stimulator (OFS) implanted subcutaneously delivered a weak electric current (50 µA), alternating polarity every 15 minutes for 6 weeks to encourage axonal growth from the lesion site. Wistar albino female rats were randomly divided to four gr

Statins represent a class of drugs commonly prescribed for lowering cholesterol levels, thereby reducing the risk of atherosclerotic cardiovascular disease. While accumulating evidence indicates an increased risk of peripheral neuropathy with prolonged statin use in humans, in vivo animal studies revealed an anti-nociceptive effect of these drugs without fully elucidating the underlying mechanisms. Transient receptor potential (TRP) ion channels represent a major class of receptors that are expressed in the peripheral nervous system and are involved in pain signaling. Among these channels, TRP

Insufficient evidence exists regarding the effect of nanoparticles, particularly liposomes loaded with a statin, on traumatic brain injury (TBI). We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on outcomes in mice with TBI. PEGylated liposomes loaded with atorvastatin were developed as nanoparticles to specifically accumulate in the injury region and release the drug to lessen the harmful effects of TBI. TBI was induced using the Marmarou method, applying five consecutive head impacts at 12-hour intervals with a weight of 120 g for