Topic: autophagosomes

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by extracellular accumulation of amyloid-beta. Estrogen receptors (ERs) are widely recognized as mediators of neuroprotection from various insults. Recent research has highlighted the distinction between nuclear and non-nuclear ER activation mechanisms, positioning non-nuclear ERs as a safer option, devoid of the cardiovascular and cancer risks associated with nuclear ER activation. In this study, we aimed to confirm the neuroprotective potential of PaPE-1, a novel compound that preferentially activates non-nuc

The serine-threonine kinase Ndr2 controls axonal and dendritic growth in vertebrates and invertebrates. Further work from our group has shown that Ndr2 KO mice display deficits in synapse development, and plasticity, that lead to spatial memory impairment. Moreover, the Ndr family of kinases have recently been implicated in the regulation of autophagy, which is essential for memory formation and cognitive function during ageing. Nonetheless, the question of whether Ndr2 is involved in age-related autophagy dysregulation and the cognitive decline associated with it remained. In the current stud