Topic: axonal regrowth

Schwann cells (SCs) are the principal glia of the peripheral nervous system and are in close contact with axons to ensure a fast propagation of electrical impulses. After nerve injury, myelinating SCs distal to the injury site dedifferentiate into pro-regenerative repair SCs. In a later phase after injury, repair SCs must redifferentiate into myelinating cells to provide a fully functional regenerated nerve. Meyer zu Reckendorf et al. recently showed the important role of metabolic adaptation in SC reprogramming after injury in an ex vivo nerve lesion model. In particular, lipid metabolism dow

Spinal Cord Injury (SCI) is a dramatic and irreversible event that leads to the loss of motor and/or sensory functions. After complete SCI, such as grade ASIA-A lesions, the neural tissue fails to repair causing permanent neurological deficits. Nowadays, complete SCI represents an unmet medical need, with no treatments capable to reduce cell death, heal the neural parenchyma, and promote axonal regrowth. In this work, we have identified a set of tumor-associated macrophages with neurogenic properties opening the prospective for a new effective cell therapy for neural degeneration diseases. We