ePoster · Behavioral Neuroscience
Prodromal gut dysbiosis, anhedonia and depression-like behavior in the A53T mouse model of Parkinson’s disease – the impact of social microenvironment
Olga Dubljević, Dušanka Popović, Željko Pavković, Milica Potrebić, Srbovan Maja, Emilija Brdarić, Vesna Pešić · FENS Forum 2024
The role of dysregulated gut microbiota (GM) is widely recognized as relevant to the pathogenesis of Parkinson's disease (PD), particularly in case of non-motor symptoms such as depression and anhedonia. Most transgenic mouse models of PD, however, don’t exhibit clinically relevant dysbiosis. Here, for the first time, we present the GM composition and depression-like behavior in Hualpha-Syn(A53T) transgenic mice, line G2-3, which over-express human α-synuclein and are the only model of PD that exhibits prodromal constipation. Additionally, we investigated whether sharing social microenvironmen