Topic: gut microbiota

The gut microbiota is composed of a very large number of bacteria, viruses, fungi and yeasts that play an important role in the body, through the production of a series of metabolites (including neurotransmitters), and through an essential role in the barrier function of the gut and the regulation of immunity and stress response. In this lecture I will present, based mainly on human studies but also on preclinical studies, the evidence for a role of the gut microbiota in the development of alcohol use disorder. I will show the first results of trials to test the effects of nutritional approach

Experimental autoimmune encephalomyelitis (EAE) is a laboratory model for multiple sclerosis (MS), an autoimmune disease characterized by chronic inflammation in the CNS, associated with demyelination and neurological disorders. Dysbiosis of the gut microbiota is a risk factor for MS. Probiotic strains can modulate the microbiota composition and are considered a therapeutic approach for MS.This study aimed to explore the therapeutic potential of Enterococcus faecium L-3 (E.faecium), a probiotic strain, in modulating gut microbiota, intestinal morphology, and immune responses within an EAE rat

The role of dysregulated gut microbiota (GM) is widely recognized as relevant to the pathogenesis of Parkinson's disease (PD), particularly in case of non-motor symptoms such as depression and anhedonia. Most transgenic mouse models of PD, however, don’t exhibit clinically relevant dysbiosis. Here, for the first time, we present the GM composition and depression-like behavior in Hualpha-Syn(A53T) transgenic mice, line G2-3, which over-express human α-synuclein and are the only model of PD that exhibits prodromal constipation. Additionally, we investigated whether sharing social microenvironmen