Topic: Fecal microbiota transplantation

Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes of depression and (hypo-) mania. The gut microbiome is a potential avenue through which metabolic signaling, inflammatory pathways and environmental factors influence mood disorders via the gut-brain axis. Fecal microbiota transplantation (FMT) is a translational tool for investigating the connections between the gut microbiome and the brain, and there is evidence that FMT from humans to mice can induce changes in affective behavior. In this study, we compared the behavior, gut-brain metabolomic profiles, and

Epidemiological studies have long acknowledged that only a minority of the population is at risk of losing control over alcohol consumption. Aiming at identifying the roots of this vulnerability, ongoing evidence from our laboratory revealed a significant vulnerability to lose control over alcohol consumption in male Wistar rats subjected to a chronic mild unpredictable stress (CMUS) during adolescence. This excessive alcohol seeking behaviour correlated with significant changes in the gut microbiota composition. Most importantly, Fecal Microbiota Transplantation (FMT) from resilient to vulner

Stroke is currently the second leading cause of death worldwide, and it accounts for approximately 3-7% of total healthcare expenditures worldwide. Cerebral ischemic stroke has known to cause irreversible damage to the brain by variety mechanisms of excitotoxicity and apoptosis within hours after hypoxic challenge. Recent evidence suggests that a ketogenic diet may reduce infarct volume and neuronal damage in ischemic stroke models. However, the connection between physiological changes induced by the diet with the pathological alterations in hypoxic susceptibility remains unclear. In this rese