Topic: base editing therapies

Support clinical development of gene and base editing therapies through pharmacokinetic, pharmacodynamic and quantitative systems models. The role connects nonclinical and clinical analyses to study design, regulatory documents and programme decisions, and helps develop the clinical pharmacology function. It can emphasise pharmacometrics or combine pharmacometrics with clinical pharmacology. Based in Cambridge, Massachusetts.

Lead the medical and clinical development strategy for Beam’s metabolic disease franchise. The role shapes clinical plans and study protocols for base editing therapies, oversees ongoing trials and patient safety, and coordinates clinical and regulatory strategy. Responsibilities include mentoring physicians and clinical scientists and working with research teams on subsequent therapeutic programmes. This hybrid role requires residence within commuting distance of Cambridge, Massachusetts.