Topic: benzodiazepine

It is not unusual to tacitly conflate conjectured inhibitory processes in cognition with inhibitory neural mechanisms. Here, we investigate whether resolution of memory interference, which is thought to entail cognitive inhibition, could be modulated by systemically administered GABAergic pharmacons in non-human primates.Twelve healthy adult rhesus macaques had been extensively trained in the PAL object-location working memory task on the Monkey CANTAB touchscreen test device. In each trial of the PAL task, the animals had to recall the locations of 3-7 distinct sequentially presented schemati

Sleep is an essential biological need that is regulated by multiple brain networks. The hypothalamus is a structure that is essential for the maintenance of physiological homeostasis including food intake, reproduction and sleep-wake states. The lateral hypothalamic area (LH) encompasses various cell groups critical for the coordination of arousal and REM sleep. In contrast, the preoptic area (POA) of the anterior hypothalamus is involved in the NREM sleep regulation. The predominant concept is that hypothalamic cells that govern sleep-wake states are clustered into wake-on, NREM-on or REM-on