Topic: biophysical modeling

There is a substantial effort, and cost, invested towards biophysical modeling of brain networks. Practically all biophysical models of voltage-activated conductances use Hodgkin-Huxley (HH) mechanisms obtained at an experimental temperature and adjusted to a modeling temperature. To do so, all models use the temperature correction factor Q10, which is assumed fixed. By performing an analysis of published data of the reaction rates of sodium, potassium, and calcium membrane conductances, we demonstrate: 1) Q10 is indeed temperature dependent; 2) this relationship is quantitatively and qualitat

Cortical circuits are built from diverse collections of neurons. Recent large-scale surveys have characterized this striking variability in terms of molecular, morphological, and electrophysiological features, identifying hundreds to thousands of distinct neuronal cell types. However, in computational neuroscience, we often stick our heads in the sand and ignore these details, instead basing theory on homogeneous populations of simple ‘point neurons'. The problem with this approach is that it's currently unknown what is lost with such simplifying assumptions. The simplification may be entirely