Biophysical parameters

The electrical behavior of neurons depends on their morphology as well as various biophysical characteristics including passive membrane and intracellular properties and the identities and densities of voltage-gated ion channels. However, some of these parameters are often not sufficiently constrained by the available experimental data and need to be inferred from the response of the neuron to specific external stimuli. Data-driven models have proved to be useful in this context; one approach is to tune the unknown parameters in the model until the output of the model best approximates the tar

…connectivity but they have different biophysical parameters, reflecting uncertainty in neuronal and synaptic properties. We find that the connectome is often insufficient to constrain the dynamics of networks that perform a specific task, illustrating the difficulty

…TVB models link biophysical parameters at the cellular level with systems-level functional neuroimaging signals. Data available from animal models can provide vital constraints for the linkage across spatial and temporal scales. I will describe the construction of a macaque cortical connectome as an initial step towards a comprehensive multi-scale macaque TVB model. I will also describe our process of validating the connectome and show an example simulation of macaque resting-state dy