A macaque connectome for simulating large-scale network dynamics in The VirtualBrain
Schedule
Friday, April 30, 2021
07:00 UTC
Kelly Shen
Dr.
University of Toronto
Host: Open Source Neuro
Recording
Open recording
Event Information
Recording
Available
Host
Open Source Neuro
Duration
70 minutes
Abstract
TheVirtualBrain (TVB; thevirtualbrain.org) is a software platform for simulating whole-brain network dynamics. TVB models link biophysical parameters at the cellular level with systems-level functional neuroimaging signals. Data available from animal models can provide vital constraints for the linkage across spatial and temporal scales. I will describe the construction of a macaque cortical connectome as an initial step towards a comprehensive multi-scale macaque TVB model. I will also describe our process of validating the connectome and show an example simulation of macaque resting-state dynamics using TVB. This connectome opens the opportunity for the addition of other available data from the macaque, such as electrophysiological recordings and receptor distributions, to inform multi-scale models of brain dynamics. Future work will include extensions to neurological conditions and other nonhuman primate species.
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