Topic: brain activation

The µ-opioid receptor (MOP) plays a pivotal role in mediating both the therapeutic effects and abuse potential of opioid drugs. However, the comprehensive understanding of the large-scale brain effects resulting from MOP activation remains elusive. In this study, we introduce a multimodal experimental pipeline combining awake functional ultrasound (fUS) imaging through the intact skull with behavioural and molecular measurements to assess the dynamics and physiological relevance of opioid-induced changes in brain activation and functional connectivity (FC) patterns. Application of the major op

Spatial locations can be encoded and maintained in working memory using high-precision, fine-grained representations that are cognitively demanding, or coarse and less demanding categorical representations. In this study, we employed an individual differences approach to identify brain activity correlates of the use of fine-grained and categorical representations in spatial working memory. We combined data from six fMRI studies, resulting in a sample of 158 (78 women, 25 ± 6 years) healthy participants performing a spatial working memory task. Our results showed that individual differences in