Brain connectivity

This funding announcement, issued by the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, seeks transformative, cutting-edge, and innovative research that embraces new technologies, ideas, and approaches to understand brain circuit function and contributions to behavior. It is a component of the BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS) Program, which aims to lay the scientific foundation for the next generation of neural circuit-based approaches for preventing and treating devastating brain disorders. This Notice of Funding Opportunity (NOF

Neuroscience is experiencing unprecedented growth in dataset size both within individual brains and across populations. Large-scale, multimodal datasets are transforming our understanding of brain structure and function, creating opportunities to address previously unexplored questions. However, managing this increasing data volume requires new training and technology approaches. Modern data technologies are reshaping neuroscience by enabling researchers to tackle complex questions within a Ph.D. or postdoctoral timeframe. I will discuss cloud-based platforms such as brainlife.io, that provide

…connecting genetic diversity with brain connectivity. It also considers research conducted with autistic people and families, and how that participation can inform care, education, inclusion and efforts to reduce stigma.

…CTD clinical manifestation follows brain creatine (Cr) deficiency and predominantly leads to neurological symptoms such as intellectual disability, language disturbance, psycho-motor impairment, autistic-like behavior, and seizures. We used a murine model to probe whether perinatal adeno-associated virus (AAV)-mediated expression of a functional SLC6A8 transgene under the control of a ubiquitous promoter could restore creatine transporter (CRT) expression and brain Cr level, thus pr

Aim: To investigate brain dynamics supporting rhythmic sensorimotor synchronization when coupling auditory and visual inputs related to walking movement using an EEG-frequency tagging approach. To investigate whether visual, audio, and audiovisual input related to walking movement may induce brain connectivity coupling between different brain areas. Methods: We used a mixed-model study design presenting both auditory (footstep sound) and visual (walking point-light-figure) inputs. Sensory inputs were presented at different frequency rates (1 Hz, 2 Hz, 3.6 Hz) in a rhythmic or random sequence w

…development, leading to alterations in brain connectivity.Thus, we placed pregnant mice on either a KD or a control diet (CD), starting from gestational day 8.5. KD

Down syndrome (DS) patients who show mental retardation also present acquired anosmia, i.e., the loss of odor detection. At the present time, no viable treatment exists for cognitive and olfactory deficits in DS. Interestingly, the ability to reach puberty and become fertile is also affected in these patients. An intriguing candidate, whose absence could mediate most of these phenotypes, is the gonadotropin-releasing hormone (GnRH), the neurohormone controlling reproduction. However, whether GnRH plays a role in the age-related cognitive decline in DS is unknown.We showed in Ts65dn mice, a wel

Structural motif analysis seeks to better understand brain connectivity by interrogating the long-range axonal projections that link distant brain regions at the single-cell resolution. This approach is enabled by MAPseq, a novel experimental methodology which labels cellular projections with viral barcodes. This recontextualizes single-neuron tracing as a problem of sequencing, overcoming the throughput limitations of prior optical techniques and capitalizing on the swift advancement of modern sequencing technology.Current MAPseq-based long range projection motif analysis methods rely on the

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, including long-lasting cognitive impairment – linked to disrupted brain connectivity. Phospholipids (PL) are key components of cellular membranes, also essential for synaptic structural integrity. It has been shown that the multi-nutrient combination Souvenaid® which contains PL precursors, improves neurological outcomes in experimental TBI. We hypothesised that this intervention could support brain recovery, and we tested the feasibility of providing this multi-nutrient to TBI patients.In a randomised, placebo-controlle

Traumatic brain injury (TBI) is the leading cause of death in the pediatric stage, with detrimental consequences including psychosocial issues, cognitive deficits and motor abnormalities. In addition to the primary TBI impact, the subsequent neuroinflammatory response can become a contributing and even leading factor to the harmful effect of pediatric TBI on the brain. As such, finding ways to stabilize the reactive microglial phenotype is a key objective for TBI treatment. One potential factor is the neuropeptide oxytocin. Oxytocin has shown to be neuroprotective in adult neuroinflammatory st

Founded in 2002, the Brain Connectivity Workshop (BCW) is an annual international meeting for in-depth discussions of all aspects of brain connectivity research. By bringing together experts in computational neuroscience, neuroscience methodology and experimental neuroscience, it aims to improve the understanding of the relationship between anatomical connectivity, brain dynamics and cognitive function. These workshops have a unique format, featuring only short presentations followed by intense discussion. This year’s workshop is co-organised by Wellcome, putting the spotlight on brain connect

The application of neuroimaging methods to marketing has recently gained lots of attention. In analyzing consumer behaviors, the inclusion of neuroimaging tools and methods is improving our understanding of consumer’s preferences. Human emotions play a significant role in decision making and critical thinking. Emotion classification using EEG data and machine learning techniques has been on the rise in the recent past. We evaluate different feature extraction techniques, feature selection techniques and propose the optimal set of features and electrodes for emotion recognition.Affective neuros

…regarding how psychedelics affect the brain. The Computational Neuroscience Laboratory at the Turner Institute for Brain and Mental Health, Monash University, uses multimodal neuroimaging to test hypotheses of the brain’s functional reorganisation under psychedelics, informed by the accounts of hierarchical predictive processing, using dynamic causal modelling (DCM). D

A major challenge of cognitive neuroscience is to understand how the brain as a network gives rise to our cognition. Simultaneous [18F]-fluorodeoxyglucose positron emission tomography functional magnetic resonance imaging (FDG-PET/fMRI) provides the opportunity to investigate brain connectivity not only via spatially distant, synchronous cerebrovascular hemodynamic responses (functional connectivity), but also glucose metabolism (metabolic connectivity). However, how these two modalities of brain connectivity differ in their relation to cognition is unknown. In this webinar, Dr Katharina Voi

While time-averaged dynamics of brain functional connectivity are known to reflect the underlying structural connections, the exact relationship between large-scale function and structure remains an unsolved issue in network neuroscience. Large-scale networks are traditionally observed by correlation of fMRI timecourses, and connectivity of source-reconstructed electrophysiological measures are less prominent. Accessing the brain by using multimodal recordings combining EEG, fMRI and diffusion MRI (dMRI) can help to refine the understanding of the spatio-temporal organization of both static an

The human brain is a complex network of neuronal connections. The precise arrangement of these connections, otherwise known as the topology of the network, is crucial to its functioning. Recent efforts to understand how the complex topology of the brain has emerged have used generative mathematical models, which grow synthetic networks according to specific wiring rules. Evidence suggests that a wiring rule which emulates a trade-off between connection costs and functional benefits can produce networks that capture essential topological properties of brain networks. In this webinar, Professor

The human brain is a heavily interconnected structure giving rise to complex functions. While brain functionality is mostly revealed during wakefulness, the sleeping brain might offer another view into physiological and pathological brain connectivity. Furthermore, there is a large body of evidence supporting that sleep mediates plastic changes in brain connectivity. Although brain plasticity depends on environmental input which is provided in the waking state, disconnection during sleep might be necessary for integrating new into existing information and at the same time restoring brain effic

…a read-out of, local and long-range brain connectivity. In fact, slow waves do not only track changes related to both experience-dependent plasticity and brain maturation during development, but also appear to be actively involved in the fine regulation of brain plasticity and