Topic: BRAIN Initiative

Develop sensor technologies that quantify behaviour and synchronise those measurements with neural activity. The BRAIN Initiative call supports methods capable of capturing richer interactions among brain activity, behaviour and the surrounding environment, with emphasis on practical research utility. U01 projects may last up to five years, and individual budgets should reflect project needs. The next application deadline is 15 June 2027 at 5 p.m. in the applicant organisation’s local time. The programme-wide funding allocation is not an individual award limit.

This NIH BRAIN Initiative R01 supports development and validation of transformative tools for cell-specific and circuit-specific analysis in the nervous system. Priorities include precise genetic and non-genetic targeting, molecular sensors, minimally invasive repeated measurements, scalable single-cell assays, cross-species tools, and technologies that break current barriers in monitoring or manipulating neural circuits.

This NIH BRAIN Initiative opportunity supports dissemination of existing resources into neuroscience research practice. Activities may include distribution of tools and reagents, training in new technologies, access to technology platforms or specialized facilities, minor improvements to resource delivery, and adaptations for user communities.

This NIH BRAIN Initiative funding opportunity supports new or substantially advanced theories, mechanistic or predictive models, and computational or statistical methods that improve quantitative understanding of brain function across scales. Tools must address complex neural and behavioral data and be made broadly available to the neuroscience research community.