Brain structure

Brain tissue comprises an extremely complex arrangement of cells that together make up the information- processing network enabling brain function. The connectivity of neurons underlies the unparalleled capabilities of our mind. Thus, mapping brain structure, which underlies brain function, has become a central focus in neuroscience.Electron microscopy provides extremely high resolution and comprehensive visualization of brain structure but requires correlative workflows to access molecular information. Light microscopy holds tremendous potential to analyze the ultrastructure of brain tissue t

Multiple risk factors contribute to the rate of atrophy in brain aging. In large population studies, we have previously shown that adverse life history, mental and cardiovascular health impact brain structure and cognition in later life, in cross-sectional investigations. Here we investigate the impact of multiple psychosocial adversities on brain structure changes in a longitudinal design using the UK Biobank dataset. Imaging-derived phenotypes (IDPs) of grey matter and measures of white matter tract integrity were analysed from two waves of data (94%: 2-3 years difference). IDPs were correct

…(VBM and SBM), was aimed to examine brain structure of pediatric OBPP patients, to better understand effects of this peripheral condition on early brain development. Methods. Thirty-six T1-weighted images of 18 patients (2-17 years old, mean age=11.3, 8 females) and 18 healthy controls (HC) (2-17 years old, mean age=10.1, 8 females) were collected via Philips Ingenia ElitionX 3.0T scanner. MRI data were processed and analyzed us

…diversity: Integrating variability in brain structure and function into personalized / closed-loop non-invasive brain stimula

…can shed light on our understanding of brain structure and function. Further, I show that we now have or are developing the data and analytical methods necessary to study the natural history of the human mind.

…neuroscience research focuses on how brain structure plasticity & evolution are affected by social behavior, mainly using insects as models. He is also interested in tropical ecology & thermal physiology. He conducts field research & teaches field courses in Central & South America, as well as in the Negev Desert in Israel.

Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases and thus microglia as the brain´s immunocompetent and instrumental cells has come into focus in sex specific studies. We and others show that male microglia are more frequent in specific brain areas and appear to have a higher potential to respond to stimuli, whereas female microglia seem to acquire a more “protective” phenotype.