Brain tumors

…redirected CAR T cells for malignant brain tumors, including glioblastoma, tumor heterogeneity, immunosuppressive microenvironments, delivery routes, and manufacturing.

…stroke, vascular malformations, and brain tumors. With broader clinical adoption, its practical strengths — as well as important limitations — have become increasingly clear.

Background: Radiotherapy is a common treatment for brain tumors, yet it often leads to cognitive decline. Past understanding suggested this damage was irreversible due to DNA damage and cell death. However, recent studies propose that it may be reversible, as it affects active cells. Scientists focus on hippocampal activity, crucial for learning and memory, to explore this. Radiation is thought to decrease neurogenesis and increase neuroinflammation in the hippocampus. Anti-inflammatory drugs are suggested as a potential solution to mitigate cognitive decline from radiation.Aims: Analyzing the

…pathophysiological effects of the brain lesion on sleep ability in our patients, and as indicated by the available literature. To assess sleep quality of patients with neuroradiologically proven brain tumors, participants completed The Pittsburgh Sleep Quality Index questionnaire. After obtaining the pathological diagno

X-ray-based radiotherapy is a standard treatment for brain tumors. However, it is associated with systemic effects like lymphopenia that correlates with poor prognosis. Protontherapy has emerged as a new strategy, given that its ballistic properties (lower entry dose and lack of an exit dose) are exploited to spare healthy brain tissue and reduce side effects caused by systemic inflammation. We investigated how protons could spare circulating leukocytes relative to x-rays and if observed effects could be mediated by ballistic, biologic effects or both. Tumor-free C57BL/6 mice model was used fo