Topic: Brg1

The kinase Mammalian Target of Rapamycin (mTOR) plays a pivotal role in cellular metabolism and growth across diverse cell types. In neurons, mTOR assumes critical importance for both neuronal development and plasticity. Dysregulation of mTOR has been implicated in mTORopathies, including Tuberous Sclerosis Complex (TSC) and associated brain disorders like epilepsy. Despite its predominant cytoplasmic localization, several studies have reported the presence of mTOR in the nucleus. Through mass spectrometry analysis, we identified Brg1, the catalytic subunit of the BAF chromatin remodelling com

The Brahma-related gene 1 (Brg1) encodes the catalytic subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, which regulates gene expression by relaxing chromatin structure, allowing greater access to transcription factors and repressors. Although the involvement of SWI/SNF-regulated genes in conditions such as autism spectrum disorder and epilepsy has been established, the specific contribution of Brg1 to epileptogenesis has not been well characterized. Using various tools, including pharmacological treatment, genomic manipulation with the CRISPR/Cas9 system in