Topic: BRI2

Development of pro-neurogenic therapies for compensating the neuronal loss and restoration of degenerated synaptic networks in neurodegenerative diseases has been difficult to achieve, which calls for new strategies to promote adult neurogenesis and counteract neurodegeneration. BRI2 is a ubiquitously expressed transmembrane protein that undergoes proteolytic processing, resulting in the formation of several secreted peptides. The precise physiological function of BRI2 remains elusive, however preliminary results suggested an increase in BRI2 levels during neuronal development, and a strong ph

Central nervous system (CNS) neurons have a limited capacity to spontaneously regenerate following injury and in neurodegenerative diseases, which calls for new pro-neurogenic strategies to counteract neurodegeneration. Therefore, understanding neuronal differentiation, function and plasticity by identifying key factors/modulators is a crucial demand to expand the knowledge on CNS ability to reorganize and adapt in res lesions response. BRI2 is a transmembrane protein, which undergoes proteolytic processing, resulting in generation of several secreted peptides whose function remains unknown. P