Topic: CA1 region

The centre of memory is the medial temporal lobe (MTL) and especially the hippocampus. In our research, a more flexible brain-inspired computational microcircuit of the CA1 region of the mammalian hippocampus was upgraded and used to examine how information retrieval could be affected under different conditions. Six models (1-6) were created by modulating different excitatory and inhibitory pathways. The results showed that the increase in the strength of the feedforward excitation was the most effective way to recall memories. In other words, that allows the system to access stored memories m

The hippocampus (HC) plays a pivotal role in spatial navigation and memory in the human brain. Place cells, specialised neurons residing within the hippocampus, exhibit selective firing patterns corresponding to specific spatial locations, collectively contributing to the cognitive mapping of the environment. In healthy state, the place fields in the CA1 region exhibits continuous representational turnover [1]. Spatial navigation is disrupted in Alzheimer’s Disease (AD). AD, a neurodegenerative disorder characterised by progressive cognitive decline, is associated with deficits in learning a