Topic: Calcitonin Gene-Related Peptide (CGRP)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), Calcitonin Gene-Related Peptide (CGRP) and Vasoactive intestinal peptide (VIP) are multi-functional neuropeptides that have been linked to debilitating conditions such as migraine. Moreover, Anti-PACAP and anti-CGRP antibodies have demonstrated clinical efficacy in Phase II and Phase III trials for treatment of migraine, respectively. Due to considerable homology and structural similarities, VIP and PACAP can bind to and signal via the same three functional G-Protein Coupled Receptors (GPCR), PAC1R, VPAC1R and VPAC2R. CGRP on the othe

Chronic pain affects 20% of the adult population, particularly the elderly, and worsens cognitive impairment. Chronic pain includes conditions such as arthritis, neuropathic pain, or certain sexual dysfunctions. Based on this clinical relationship with vulvodynia, we conducted a study on CGRPergic innervation in the dorsal horn of the spinal cord and the female external genitalia in different age groups.Immunohistochemistry was performed against calcitonin gene-related peptide (CGRP) in the lumbosacral enlargement and vulva of adult (60, 70 years) and elderly (84, 85 years) human cadaveric don