Topic: calcium dynamics

Behavior varies even among genetically identical animals raised in the same environment. However, little is known about the circuit or anatomical underpinnings of this individuality, though previous work implicates sensory periphery. Drosophila olfaction presents an ideal model to study the biological basis of behavioral individuality, because while the neural circuit underlying olfactory behavior is well-described and highly stereotyped, persistent idiosyncrasy in behavior, neural coding, and neural wiring have also been described. Projection neurons (PNs), which relay odor signals sensed by

behaviour varies even among genetically identical animals raised in the same environment. However, little is known about the circuit or anatomical underpinnings of this individuality, though previous work implicates sensory periphery. Drosophila olfaction presents an ideal model to study the biological basis of behavioural individuality, because while the neural circuit underlying olfactory behaviour is well-described and highly stereotyped, persistent idiosyncrasy in behaviour, neural coding, and neural wiring have also been described. Projection neurons (PNs), which relay odor signals sensed

Understanding the mechanisms regulating Ca2+ concentrations in the presynapse is crucial for synaptic function. The endoplasmic reticulum (ER) acts as a finite calcium store and can modulate calcium signals involved in presynaptic neurotransmitter release. While computational studies have shed light on the spatiotemporal dynamics of calcium in dendritic spines, the distribution of channels along synaptic and ER membranes and their modulation of calcium dynamics remain unclear. We investigated the influence of calcium exchange in different spatial compartments and the dynamics of calcium concen