Topic: calcium homeostasis

Antidepressant treatment during pregnancy may endanger neurodevelopment of the offspring. Cellular parameters (hippocampal homeostasis) and physiological parameters (behavioral aspects) in the offspring of Mirtazapine treated and depressed mothers are not yet fully described. We evaluated changes in cellular calcium homeostasis (Fura2AM) and CaV1.2 expression, presence of mitochondrial superoxide radicals (MitoSOXTM) together with behavior of developing pups.As an experimental model of perinatal depression we used pre-gestational exposure to chronic unpredictable stress followed by Mirtazapine

Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in the hours to days after impact (secondary damage). Cortical spreading depolarization (CSD) is a metabolically demanding processes that may worsen the secondary brain injury. Metabolic stress has been associated with mitochondrial dysfunction, including impaired calcium homeostasis and elevated ROS production. However, the association between mitochondrial impairment and vascular function after TBI is poorly understood. We therefore aimed to 1) Identify the role of CSD on neurological outcome after TBI,