Topic: calcium-permeable AMPA receptors

The reward and novelty-related neuromodulator dopamine has been implicated in protein synthesis-dependent plasticity and is important for long-term memory. However, the direct effects of dopamine on protein synthesis rates and the functional implications of the newly synthesized proteins remain largely unknown. Here, we show that dopamine increases the rate of protein synthesis in hippocampal neurons in CA1, enabling dopamine-dependent long-term potentiation (DA-LTP). Neuronal activity is required for the dopamine-induced increase in protein synthesis, and we found that DA-LTP is mediated by t

Alzheimer's disease (AD) is a major neurodegenerative disease characterized by a marked decline in the activity of the alpha-ketoglutarate dehydrogenase complex (AKGDHC), a key metabolite of the tricarboxylic acid (TCA) cycle. Earlier studies have shown that the calcium salt of AKG, CaAKG, increases the healthspan and lifespan in C57BL/6 mice by reducing inflammatory cytokines. Here, we demonstrate that CaAKG attenuates long-term potentiation (LTP) in an animal model of AD, APP/PS1 mice. CaAKG application during strong tetanisation converts early-LTP to late-LTP, stable for 4 hours in the CA1