Cancer metastasis

…and metabolic alterations shape cancer progression, metastasis and responses to radiation therapy. The postdoctoral scholar contributes to both lab programmes: metastasis and tumour metabolism (lipid metabolism, hypoxia, redox biology and the tumour microenvironment in metastatic adaptation) and FLASH radiation biology (how iron metabolism and redox state influence tumour and normal-tissue responses to ultra-high dose-rate versus conv

…embryo development, wound healing and cancer metastasis. In many of these situations, tissues are able to tune themselves between liquid-like states, where cells flow collectively as in a liquid, and solid-like states that can support shear stresses. In this talk I will describe mesoscopic models of cell assemblies inspired by active matter physics to examine the roles of cell motility, cell crowding and the interplay of contractility and adhesion in controlling the rheological state of biological tissu