Topic: Canonical Correlation Analysis

An animal’s dominance status strongly affects its behavioural decision making in social contexts. While the thalamocortical circuitry involved in the establishment of male mouse social status has received much attention in the literature, it remains unclear how these representations of rank modulate downstream areas to yield distinct behavioural phenotypes. Here we report in vivo miniscope recordings from the medial preoptic area (MPOA) and the ventromedial hypothalamus (VMH) - two areas involved in social decision-making that show differential c-Fos expression depending on social rank. Record

Neural networks are now widely used for modeling neural activity in the brain. They have been particularly successful in modeling the visual system, using mostly feedforward networks and leveraging community-wide efforts centered around benchmarks to both improve model architectures and evaluate model fits to data. Now that recurrent neural networks (RNNs) are also used to model a larger variety of brain functions, there is a similar need for developing appropriate metrics to compare these models. Towards this goal, we have built a high-throughput pipeline for training different RNN models on

In the mouse visual cortex, neural representations of stimuli fluctuate across repetitions (Schölvinck et al. 2015, Deitch et al. 2021). The single-trial dynamics, often termed as representational drift, were also found in other cortical structures (Rokni et al. 2007, Low et al. 2021, Schoonover et al. 2021). However, most of these studies focused on slow drift over days. Here, we demonstrated that representational drift occurs at a fast timescale of several minutes and is prevalent regardless of stimulus type and independent of behavioral state. Within sessions of the same day, repeats of the

The genome governs the developmental trajectory of neural circuits [1, 2], guiding processes like neurogenesis and synaptogenesis to ultimately shape the structure of the brain. Here, we study the impact of genetic variation during development on the dynamics and geometry of neural population activity in the motor cortex (MOp) of adult mice during natural feeding behavior. We focus on autism spectrum disorder (ASD) models, many cases of which are characterized by stereotypical motor impairments [3]. Specifically, we compare neural activity during a dexterous cued self-feeding task in two trans

Constructing well-motivated methodologies for quantifying similarity between high-dimensional neural representations is an active research in computational neuroscience. Such similarity measures have implications for understanding variability in neural computations across individuals and species [1], as well as for comparisons between biological systems and computational models [2]. One common approach to understand these systems is to build regression models or “decoders” that reconstruct features of the stimulus from neural responses. Here, we leverage this idea to quantify the similarity of

Resting-state functional connectivity (FC) has received considerable attention in the study of brain-behavior associations. However, the low generalizability of brain-behavior studies is a common challenge due to the limited sample-to-feature ratio. In this study, we aimed to improve the generalizability of brain-behavior associations in resting-state FC by focusing on diverse and stable edges, i.e., edges that show both high between-subject and low within-subject variability. We used resting-state data from 1003 participants with multiple fMRI sessions from the Human Connectome Project to gro

A major challenge in studying spatial memory is understanding whether and how different navigational strategies influence hippocampal spatial representations of the environment.We designed a spatial recency memory task with two variants: one requiring allocentric representations of location, the other entailing egocentric representations. 10 freely-moving rats were trained over 34 daily sessions; each day, rats learned and then recalled the position of a food reward among six locations. Each trial, animals entered the arena from one of four start locations, generating distinct origin-goal traj