Topic: CB2 receptor

Stroke is a leading cause of long-term disability worldwide with substantial economic costs. Hence, there is an urge for finding novel therapies to treat disability associated to stroke. This is the main reason research has focused on the discovery of key molecules involved in the functional prognosis of patients after stroke. Adenosine A2A and CB2 are receptors that have proven to be a new therapeutic target to consider in treatment of stroke. A common feature of these receptors in neurons is that their expression is upregulated in neuroinflammation process. On the one hand CB2R show a neurop

Aging is epitomized by a progressive increase in neuroinflammation which is associated with altered brain states, neuronal death and eventually neurodegeneration disease. Microglia are the resident macrophagic cells of the brain that play a crucial role in maintaining homeostasis and immune response especially during neuroinflammation. The endocannabinoid system (ECS) is a negative feedback signalling system that helps to maintain homeostasis. The ECS is able to modulate microglia activation states and functions through the endocannabinoid receptors CB1 and CB2. Although, the role of ECS and m