Topic: cell loss

Lead experimental studies that identify and validate targets for neurodegenerative disease. Design rodent experiments, analyse human and animal brain tissue, and develop quantitative measures of protein aggregation, inflammation, cell loss and vascular integrity. Collaborate with pharmacology, histology, molecular biology and computational teams to turn mechanistic findings into programme decisions. The employer’s current vacancy accepts applications without a stated fixed deadline.

Traumatic brain injury (TBI), a leading cause of acquired epilepsy, results in primary cellular injury as well as secondary neurophysiological and inflammatory responses which contribute to epileptogenesis. I will present our recent studies identifying a role for neuro-immune interactions, specifically, the innate immune receptor Toll-like receptor 4 (TLR4), in enhancing network excitability and cell loss in hippocampal dentate gyrus early after concussive brain injury. I will describe results indicating that the transient post-traumatic increases in dentate neurogenesis which occurs during th