Topic: cellular memory

Emmanuelle Passegué examines why mechanisms that maintain blood-forming stem cells in early life can contribute to their deterioration with age. The lecture connects cell-cycle control, marrow support, inflammation, metabolic regulation and cellular memory to altered self-renewal and blood-cell production. It also considers genomic instability, clonal hematopoiesis and progression toward leukemia.

Nikolay Kukushkin connects research on cellular memory with a broader account of mind and meaning. Drawing on molecular biology, evolution and his book One Hand Clapping, he examines relationships across scales and the proposal that minds are continuous with the processes and environments from which they emerge.