Seminar, Hosted by Collège de France
Hematopoietic Stem Cell Aging and Adaptation to Stress
Director of the Columbia Stem Cell Initiative and Professor Emeritus of Genetics and Development at Columbia University
- Hematology, Cell Biology and
Abstract
Emmanuelle Passegué examines why mechanisms that maintain blood-forming stem cells in early life can contribute to their deterioration with age. The lecture connects cell-cycle control, marrow support, inflammation, metabolic regulation and cellular memory to altered self-renewal and blood-cell production. It also considers genomic instability, clonal hematopoiesis and progression toward leukemia.