Principle of Hematopoietic Stem Cell Biology and Blood Production
Video page · Nov 7, 2025
Emmanuelle Passegué, Director of the Columbia Stem Cell Initiative and Professor Emeritus of Genetics and Development at Columbia University
Hematopoietic Stem Cell Aging and Adaptation to Stress
Hematology, Cell Biology, Gerontology and seminar by Emmanuelle Passegué, Director of the Columbia Stem Cell Initiative and Professor Emeritus of Genetics and Development at Columbia University
Hosted by Collège de France
Tuesday 17:30–18:30 Paris (GMT+1)
Recording available
Amphithéâtre Mireille-Delmas-Marty, Site Marcelin-Berthelot · In person
Abstract
Emmanuelle Passegué examines why mechanisms that maintain blood-forming stem cells in early life can contribute to their deterioration with age. The lecture connects cell-cycle control, marrow support, inflammation, metabolic regulation and cellular memory to altered self-renewal and blood-cell production. It also considers genomic instability, clonal hematopoiesis and progression toward leukemia.
Topics
cell-cycle controlinflammationmetabolic regulationcellular memoryself-renewalgenomic instabilityClonal hematopoiesisleukemia
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