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Seminar, Hosted by Collège de France

Environmental Crosstalk and Bone Marrow Niche Regulation

Emmanuelle Passegué

Director of the Columbia Stem Cell Initiative and Professor Emeritus of Genetics and Development at Columbia University

Abstract

This lecture examines how bone-marrow structure and stromal cells regulate blood-forming stem and progenitor cells. It reviews technologies that reveal the spatial organisation and signalling relationships of these populations. Particular attention is given to mesenchymal stromal cells, blood-lineage production and responses to infection and inflammation.

Topics