Progenitor cells

…and metabolic responses of stem and progenitor cells that accelerate myeloid-cell output. It then examines how persistent or misdirected activation of these emergency mechanisms can contribute to chronic inflammatory disease and cancer.

This lecture examines how bone-marrow structure and stromal cells regulate blood-forming stem and progenitor cells. It reviews technologies that reveal the spatial organisation and signalling relationships of these populations. Particular attention is given to mesenchymal stromal cells, blood-lineage production and responses to infection and inflammation.

…during development by neural stem and progenitor cells. Epigenetic mechanisms play a pivotal role in orchestrating the behaviour of stem cells during development. We are interested in the mechanisms that regulate gene expression in neural stem cells, which have implications for our understanding of neocortex development an

…particularly linked to neural stem and progenitor cells. Key mechanisms include high rates of neurogenesis, high abundance of basal Radial Glia Cells (bRGCs), and neuron migration, all of which are intertwined during development. We have also shown that primary cortical folds follow highly stereot

…Molina will deal with the “Tuneable progenitor cells to build the cerebral cortex”, and Prof Tomasz Nowakowski will present “Charting the molecular 'protomap' of the human cerebral cortex using single cell genomic”.

…that the retina has distinct types of progenitor cells that are biased, or committed, to produce distinct types of daughter cells in terminal divisions. The gene regulatory networks that underlie these cell fate choices are being studied by analysis of both gene function and cis-regulatory networks. New methods that enable these studies have been developed, including high throughput enhancer assays and quantitative, inexpe