Topic: infection

Laura Graus explains a multi-omics workflow that combines B-cell receptor repertoire analysis with phenotypic profiling using dCODE Klickmer technology. The seminar examines how the pipeline characterizes B-cell responses after vaccination and infection, including the function and dynamics of memory B-cell reactivation. Its application to vaccination studies illustrates how single-cell measurements can inform HIV-1 vaccine design.

Julia Kaltschmidt investigates whether signaling between the gut and brain helps explain persistent fatigue. She describes research on the enteric nervous system and sickness responses, including a proposed reflex that could connect infection to longer-lasting symptoms and guide future work on biomarkers.

Blood production can be rapidly reorganised after infection or marrow injury. This lecture follows the molecular, cellular and metabolic responses of stem and progenitor cells that accelerate myeloid-cell output. It then examines how persistent or misdirected activation of these emergency mechanisms can contribute to chronic inflammatory disease and cancer.

This lecture examines how bone-marrow structure and stromal cells regulate blood-forming stem and progenitor cells. It reviews technologies that reveal the spatial organisation and signalling relationships of these populations. Particular attention is given to mesenchymal stromal cells, blood-lineage production and responses to infection and inflammation.

Stephen Quake describes how circulating cell-free nucleic acids became a basis for non-invasive diagnostics. Combining genome knowledge with high-throughput sequencing made liquid biopsies useful in pregnancy, transplantation, infection and cancer. The lecture follows the development of blood-based tests that can replace some invasive tissue-sampling procedures.