Unraveling protective B cell responses in vaccination and infection at the single-cell level

Laura Graus explains a multi-omics workflow that combines B-cell receptor repertoire analysis with phenotypic profiling using dCODE Klickmer technology. The seminar examines how the pipeline characterizes B-cell responses after vaccination and infection, including the function and dynamics of memory B-cell reactivation. Its application to vaccination studies illustrates how single-cell measurements can inform HIV-1 vaccine design.