Topic: autoimmunity

Andrew Huberman and immunologist Max Krummel discuss immune function, sleep, emotions, memory, the thymus, autoimmunity, cancer and immunization.

Shimon Sakaguchi explains how regulatory T cells restrain immune responses and maintain tolerance to the body’s own tissues. He follows experimental evidence linking the removal of particular CD4 T-cell populations to autoimmune disease and the restoration of regulation to protection against excessive immune activity. The lecture connects these mouse experiments with human immune dysregulation, including IPEX, and with the role of FOXP3 in regulatory T-cell biology. It develops the idea that active cellular suppression is a continuing requirement for immune balance, with implications for unde

Parkinson's disease has been characterized by the significant role that alpha-synuclein and immune activation play in driving disease progression. Moreover, the immunogenicity of alpha-synuclein-derived epitopes in driving both innate and adaptive immunity has been discovered in prodromal Parkinson's disease. Despite these findings, the mechanistic role of the immune system in contributing to disease ontogenesis remains unknown. Recent evidence has identified alpha-synuclein as a candidate biomarker, with seed amplification assays yielding high sensitivity for sporadic cases of the disease. Pe