Central pattern generators

…with non-rhythmic input, also called central pattern generators (CPGs). However, the cellular and microcircuit implementation of a walking CPG has not been described for any limbed animal. New comprehensive connectomes of the fruit fly ventral nerve cord (VNC) provide an opportunity to study rhythmogenic walking circuits at a synaptic scale.We use a data-driven network

…with non-rhythmic input, also called central pattern generators (CPGs). However, the cellular and microcircuit implementation of a walking CPG has never been described for any limbed animal. Brand new comprehensive connectomes of the fruit fly ventral nerve cord (VNC) provide an opportunity to study rhythmogenic walking circuits at a synaptic resolution. In this project, we deve

…have shown variability in sleep patterns across different species, complicating the identification of common mechanistic principles [Siegel, 2008]. Recent evidence in non-mammalian amniotes suggests that similar sleep

…circuits in the spinal cord called central pattern generators (CPGs) and to simulate biological locomotion such as human bipedal walking (Taga et al., 1991; Ogihara & Yamazaki, 2001). However, most previous studies have overlooked its convergent dynamics toward stationary states, corresponding to transient neuronal activities and non-oscillator

Central pattern generators (CPGs) in the spinal cord control animal locomotion. They generate rhythmically alternating flexor and extensor activities producing coordinated limb movements. Afferent feedback allows animals to adapt locomotion to the environment. Responses of neural activities to afferent feedback stimulation have been previously examined during fictive locomotion in immobilized cats. However, locomotion of behaving animals is governed by dynamic interactions between central neuronal circuits (CPGs), afferent feedback, the musculoskeletal system, and the environment. To study the

Locomotion is controlled by Central Pattern Generators that elicit rhythmic locomotor movements of the limbs. These circuits located in the ventral part of the spinal cord are composed of motor neurons and interneurons. In the developing spinal cord, transcriptional regulators, including Lim-Homeodomain (Lim-HD) transcription factors, cooperate to segregate motor neurons and different interneuron subsets with distinct molecular, morphological, and functional characteristics. Based on their high sequence homology and their similar distribution, Lim-HD paralogs of the Lim3 group (Lhx3 and Lhx4)

…optogenetics, I aim to investigate the patterning and functionality of the regenerated nervous system on multiple levels from sensory input to activity to motion: (1) projection patterns, connectivity, and muscle innervation within and across muscle segments; (2) swimming behavio

Locomotion of animals is controlled by central pattern generators (CPGs) located in the spinal cord. Afferent feedback allows animals to adapt locomotion to the environment. Responses of neural activities to afferent feedback stimulation have been previously examined during fictive locomotion in immobilized cats. However, the locomotion of behaving animals is governed by dynamic interactions between central neuronal circuits, afferent feedback, the musculoskeletal system, and the environment. To study the specific role of afferent feedback in these interactions, we created a neuromusculoskelet

…Neural episode generators are required to drive the intermittent pulsatile and surge profiles of reproductive hormone secretion that control gonadal function. Studies in genetic mouse models have been fundamental in defining the neural circuits forming these central pattern generators and the full range of in vitro and in vivo optogenetic and chemogenetic methodologies have enabled investigation into their mechanism of action. The seminar will outline studies defining the hypothalamic “GnRH pulse generator network” an

…is the case for behaviors that recruit central-pattern generators (CPGs). Breathing is a particularly interesting example since it is vital for sustaining life and yet breathing is integrated into a myriad of other behaviors like speaking, laughing, and coughing. Vocalizations co-opt respiratory machinery for communication. While the generation of vocal motor commands is generally