Hypothalamic episode generators underlying the neural control of fertility
Tuesday, November 8, 2022
15:00 UTC
Professor Allan Herbison
Department of Physiology, Development and Neuroscience, University of Cambridge
Recording
Open recording
Hosted by Cambridge Neuro70 minutes
Abstract
The hypothalamus controls diverse homeostatic functions including fertility. Neural episode generators are required to drive the intermittent pulsatile and surge profiles of reproductive hormone secretion that control gonadal function. Studies in genetic mouse models have been fundamental in defining the neural circuits forming these central pattern generators and the full range of in vitro and in vivo optogenetic and chemogenetic methodologies have enabled investigation into their mechanism of action. The seminar will outline studies defining the hypothalamic “GnRH pulse generator network” and current understanding of its operation to drive pulsatile hormone secretion.
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