Cookies
We use essential cookies to run the site. Analytics cookies are optional and help us improve World Wide. Learn more.
Buzsáki Lab, NYU
Showing your local timezone
Schedule
Wednesday, July 6, 2022
7:00 PM Europe/Berlin
Recording provided by the organiser.
Domain
NeuroscienceHost
WWNeuRise
Duration
35 minutes
A key issue in understanding circuit operations is the extent to which neuronal spiking reflects local computation or responses to upstream inputs. Several studies have lesioned or silenced inputs to area CA1 of the hippocampus - either area CA3 or the entorhinal cortex and examined the effect on CA1 pyramidal cells. However, the types of the reported physiological impairments vary widely, primarily because simultaneous manipulations of these redundant inputs have never been performed. In this study, I combined optogenetic silencing of unilateral and bilateral mEC, of the local CA1 region, and performed bilateral pharmacogenetic silencing of CA3. I combined this with high spatial resolution extracellular recordings along the CA1-dentate axis. Silencing the medial entorhinal largely abolished extracellular theta and gamma currents in CA1, without affecting firing rates. In contrast, CA3 and local CA1 silencing strongly decreased firing of CA1 neurons without affecting theta currents. Each perturbation reconfigured the CA1 spatial map. Yet, the ability of the CA1 circuit to support place field activity persisted, maintaining the same fraction of spatially tuned place fields. In contrast to these results, unilateral mEC manipulations that were ineffective in impacting place cells during awake behavior were found to alter sharp-wave ripple sequences activated during sleep. Thus, intrinsic excitatory-inhibitory circuits within CA1 can generate neuronal assemblies in the absence of external inputs, although external synaptic inputs are critical to reconfigure (remap) neuronal assemblies in a brain-state dependent manner.
Ipshita Zutshi
Buzsáki Lab, NYU
Contact & Resources
neuro
Nervous system function relies on the polarized architecture of neurons, established by directional transport of pre- and postsynaptic cargoes. While delivery of postsynaptic components depends on the
neuro
A combinatorial neural code for long-term motor memory
neuro
The postdoctoral researcher will work on an interdisciplinary project at the intersection of deep learning and comparative politics. The candidate will work in the Human-Centered Machine Learning (HuM
We are looking for highly motivated researchers to join our group in interdisciplinary projects that focus on the development of computational models to understand how linguistic information is repres
The CSNG Lab at the Faculty of Mathematics and Physics at the Charles University is seeking a highly motivated Postdoctoral Researcher to join our team to work on a digital twin model of the visual sy
PROJECT SUMMARY / ABSTRACT Cluster headache (CH), which affects about 1 in 1,000 people, is a severe and debilitating primary headache disorder characterized by repeated attacks occurring in clusters