Topic: cerebral hypoperfusion

Progesterone (P4) has shown promising results in diminishing the effects of cerebral hypoperfusion (CH) in prefrontal cortex. Therefore, our goal was to further analyze the neuroprotective mechanism of P4 in adult Wistar rats following bilateral occlusion of common carotid arteries (2VO). We investigated its impact on neurological function and activity of striatal extracellular purine metabolizing enzymes, CD39 and CD73. Following either sham or 2VO operation, for 7 consecutive days, animals (n=12) received s.c. treatments of commercial flax oil (V, 1 mg/kg) (Sham+V and 2VO+V groups) or 1.7 mg

Cerebral hypoperfusion (CH) is a contributing factor to impairments observed in individuals diagnosed with Alzheimer's disease, vascular dementia and the elderly population. CH-induced brain damage is closely associated with oxidative stress (OS), manifested through disturbed prooxidative/antioxidative balance (PAB) within cells. Elevated levels of xanthine oxidase (XOD) are identified as a potential causal factor of OS, ultimately culminating in cell death. We aimed to investigate the protective effects of the hormone progesterone (P4) against CH‐induced OS and neurodegenerative pathologies i