Topic: cerebral ischemia

Stroke is a leading cause of disability and death due to the brain’s limited ability to regenerate damaged circuits. Induced pluripotent stem cell (iPSC)-based therapies are emerging as a promising therapeutic approach for stroke recovery. Here, we demonstrate that local transplantation of GMP-compatible iPSC-derived neural progenitor cells (NPCs) improve long-term recovery-associated brain tissue responses and reduce neurological deficits after cerebral ischemia in mice. Using in vivo imaging and post-mortem histology, we showed long-term graft survival over the course of five weeks and prefe

Adult cerebral ischemia (stroke) is a neurological injury caused by the occlusion of cerebral blood vessels and it is one of the leading causes of long-term disability. Notably, an ischemic stroke can occur also during brain development with the early perinatal period being characterized by critical period windows when experience provides essential information for the proper maturation of sensory, motor, and cognitive functions. Despite the large amount of evidence on adult stroke, very little it is still known about the impact of a stroke occurring during perinatal ages in the developing brai