Topic: chemogenetic modulation

The major function of primary order neurons in the ARC of the hypothalamus is control of energy homeostasis. Among these neurons, POMC neurons play a significant role in controlling anorexigenic feeding behavior and upregulating energy expenditure. Additionally, TRPM2 is a well-established temperature sensor, but no evidence of regulation of BAT thermogenesis via POMCTRPM2 neurons in the ARC has been reported to date. We here investigated the role of ARC POMCTRPM2 in BAT thermogenesis. Through single-cell RT-PCR and IHC analyses, we confirmed that some POMC neurons express TRPM2. The specific

The dopaminergic striatal circuit is a key hub for processing reward and motivation in the brain. The main cell types of this circuit are the medial spiny neurons (MSNs), which are dynamically controlled by the interneurons of the region. Among these, the cholinergic interneurons (CINs) represent only 1-3% of the total neurons of the striatum but potentially exert a fundamental role in controlling the activity of the MSNs and local dopamine release. The overarching objective of this study is to assess the role of CINs in modulating striatal dynamics. Considering their striatal localization and