Topic: cholesterol

Our aim is to investigate the effect of choline, fish oil, and uridine-5'-monophosphate (UMP) supplementation on lipid profiles in the 5XFAD mouse model of Alzheimer's disease (AD) was to characterize cholesterol, glycerophospholipids (GPLs), sphingolipids (SLs), glycolipids (GLs), lysophospholipids (lyso GPLs) and lysophospholipid acyltransferases (lyso GPL O-ATs), and glycerophospholipid (GPL Os).Lipidomic analysis was performed on hippocampal brain tissue samples from 3-, 6- and 9-month-old 5XFAD mice and littermate controls using cutting-edge mass spectrometers with direct infusion (shotgu

Apolipoprotein E (ApoE) is the major glycoprotein in the brain and plays a critical role in the transport of cholesterol and other lipids. Besides, ApoE has a crucial function in the maintenance of synaptodendritic connections, and repair of neurons. ApoE knockout (ApoE-KO) mice model whose apoE gene has been knocked out has great importance for understanding the effect of ApoE and loss of function of ApoE. Scientists have reported cognitive impairment in ApoE-KO mice, with cholinergic deficits, decreased synaptic excitability. In the present study, we investigated the difference between the b