Topic: cholinergic neuromodulation

ePoster: 2 ePosters

Cholinergic regulation of dendritic Ca2+ spikes controls firing mode of hippocampal CA3 pyramidal neurons

Noémi Kis, Balázs Lükő, Judit Herédi, Ádám Magó, Bela Erlinghagen, Mahboubeh Ahmadi, Snezana Raus Balind, Mátyás Irás, Balázs B. Ujfalussy, Judit K. Makara · FENS Forum 2024

The hippocampus is essential for spatial navigation and memory processes. Hippocampal pyramidal cells (PCs) often exhibit complex spike bursts (CSBs) that are driven by regenerative dendritic Ca2+ plateau potentials. These events can induce rapid synaptic plasticity and new place field (PF) formation in CA1PCs. CA3PCs also fire CSBs, and their PF-inducing CSBs were shown to be particularly prolonged (Li et al, bioRxiv). However, the dendritic mechanisms underlying such long-lasting events in CA3PCs remain unclear. In acute rat brain slices, we observed large heterogeneity among CA3PCs in CSB p

ePoster · Neuroscience

Vasopressin shifts the excitation-inhibition balance in the olfactory bulb network via differential effects on olfactory bulb neuron subtypes

Hajime Suyama, Gaia Bianchini, Max Müller, Luna Jammal, Veronica Egger, Michael Lukas · FENS Forum 2024

Vasopressin (VP) cells in the rat olfactory bulb (OB) have unique features compared to other types of external tufted cells, with olfactory nerve input inhibiting them and added cholinergic neuromodulation enabling them to fire. However, how VP modulates bulbar synaptic transmission to facilitate social discrimination is still unclear. As first step, we recorded responses to olfactory nerve stimulation and their modulation by VP (1 µM) using electrophysiology as well as 2-photon population Ca2+ imaging in acute OB slices. We first investigated the excitatory middle tufted and mitral cells. In

ePoster · Neuroscience