Neuromodulation

…radiology, skull-base surgery and neuromodulation. Afternoon sessions combine theory and practice in craniotomy, burr-hole technique and bone-flap fixation; pedicle-screw placement; upper-limb sensory and motor nerve-conduction studies; and catheter navigation using a neurointerventional simulator. No prior simulator experience is required. Posters and sponsor exhibits run during breaks and lunch,

…recordings to understand how neuromodulation affects brain activity and behaviour.

…and RNA regulation, together with neuromodulation, before considering circuit vulnerability and memory disruption in neurodegenerative and neuropsychiatric disorders. Novel methods and unresolved questions connect the different biological scales. A satellite symposium on synapses and c

…neurosurgery with multidisciplinary neuromodulation. The first day offers workshops on deep-brain stimulation programming, non-invasive stimulation, pain interventions, botulinum toxin and functional neurosurgical techniques. Subsequent plenaries and parallel sessions address psychiatry, neurosurgery, neurology and pain, including new technologies, clinical research and contributed papers. Sessions begin at 08:00 local time each day, with the final free-paper sessions ending at 17:45 on 9 May.

…interfaces, neuroprosthetics and neuromodulation. The programme is developed through community proposals and original research abstracts. Its scope spans clinical applications, neuroscience and neural engineering, data and AI, device technology, translation and outcomes, and ethics, policy and workforce questions. The meeting connects foundational research with implementation and adoption of neural technologies. The speaker-proposal deadline was 12 October 2026

…rapid-acting interventions, neuromodulation, and precision therapeutics.

…The prevalent view is that neuromodulation increases the flexibility of circuit output. However, different modulators can have overlapping cellular and subcellular targets, and thus convergence and occlusion may limit the repertoire of possible circuit states. We propose a complementary view that convergent comodulation may result in a more consistent circuit activity that, with increasing numbers of modulators, becomes less dependent on the specific identity of the modulators involved. We examine this h

…by both synaptic plasticity and neuromodulation. Traditional methods for extracting connectivity from activity focus on modeling static connectivity. On the other hand, recent transformer-based models are able to capture nonstationary interactions, but their deep layered structures and nonlinear attention mechanisms make them challenging to interpret, particularly in terms of

How does the brain gain insight from limited novel experience? Humans and animals have a striking ability to learn relationships between items of experience, enabling structured generalization and rapid assimilation of new information. A fundamental type of such relational learning is order learning, which enables transitive inference: if A>B and B>C, then A>C. Remarkably, both humans and animals can quickly and globally reorganize separate learned orderings upon learning a single new item ("list-linking"; learn A>B>C and D>E>F, then C>D, and infer B>E), an instance of fast "reassembly" of exi

…by synaptic plasticity, making neuromodulation a prime suspect. Neuromodulation is typically modeled as gain changes at the level of somatic activation function. As a result, gain control is limited to the number of neurons N and often proves to be too coarse for multi-muscle coordination. Moreover, somatic gain modulation cannot easily accommodate the simultaneous impact of dif

…a proposed single-neuron model, neuromodulation and possible implications for simpler AI architectures, while connecting those ideas to verbal thought, language models and the experience of establishing an independent research foundation.

…to account for such rapid changes is neuromodulation. We explore how modulation can assist a recurrent neural network to accommodate a range of variations of the tasks it is initially trained on. There are a number of approaches allowing for rapid acquisition of new tasks, for example, the neuronal gain modulation model [1]. However, we found that by affecting the input-output function of a neuron such an approach can neither address the variation of a

Neuromodulation by the locus coeruleus (LC) plays a crucial role in cognitive processes related to learning, as well as memory consolidation (DOI: 10.1038/s41583-020-0360-9). Less is known about its role in memory retrieval. In this study, we explored this aspect following training of adult rats over a period of multiple days in an 8-arm radial maze to achieve robust spatial working memory (WM) and reference memory (RM) of the task. We then examined the consequence of patterned electrophysiological activation of the LC on the retrieval of recent (24h after the conclusion of training) or remote

Epilepsy is a chronic neurological disorder that affects 1% of the world's population and is often linked with notable comorbidities and higher risks of mortality. Around 30% of epilepsies are considered pharmacoresistant (PRE). Resection surgery provides around remission in only 30-40% of eligible patients, leaving the remainder without alternative treatment options. Transcranial current stimulation (tCS) is a new safe and noninvasive approach that is increasingly being used in treating brain disorders. In the context of PRE, tCS seems to be a promising solution that aims to reduce cortical e

Down syndrome (DS) results from chromosome 21 trisomy, causing cognitive and developmental challenges often accompanied by hearing deficits. Studies on humans using EEG and MEG have identified prolonged latencies in sound-evoked responses in DS. However, the origin and characteristics of these deficits remain unclear. This study investigates auditory processing in a DS rat model to determine whether sensory deficits arise from early processing areas, such as the auditory thalamus and primary auditory cortex (A1), or higher-level cognitive alterations. We conducted neural activity recordings, u

Current neuromodulation strategies mainly rely on pharmaceutical interventions, with limited efficiency over time in chronic progressive neurodegenerative disorders. Alternate therapeutical approaches include electric neuromodulation like deep brain stimulation for Parkinson’s disease. Nowadays, a variety of neural prostheses has been successfully developed to restore damaged/lost neural functions such as the ability to communicate in a fully paralyzed patient, or to walk in cases of partial spinal lesions. However, despite proven therapeutic benefits, most available neural implants mainly rel

Insomnia is a common health problem in the general population. There are different ways to improve sleeping habits and quality of sleep; however, there is no clinical trial using transdermal neurostimulation to treat individuals with symptoms of insomnia in Asia. This gives us the impetus to execute the first study in Asia, which aims to evaluate the efficacy of electrical vestibular stimulation (VeNS) on individuals with insomnia in Hong Kong. A two-armed, double-blind, randomized, sham-controlled trial was conducted. A total of 101 adults aged 18 to 60 years with insomnia symptoms were recru

A hallmark of Alzheimer’s disease (AD) pathology is amyloid plaques which can lead to neuroinflammation, cellular dysfunctions as well as altered neuronal activity. Both AD patients and mouse models exhibit abnormal neural oscillations, including altered gamma oscillations, hippocampal sharp wave-ripples (SWRs) and cortical sleep spindles. Although these oscillations play a role in memory formation and consolidation, it remains poorly understood how abnormal oscillations relate to novel experiences. Here we show that deficits in SWRs are experience-dependent in an AD mouse model. We performed

…a large number of genes that regulate neuromodulation and plasticity, indicating that the plasticity deficits have a genetic origin. Here, we used biochemically detailed computational modelling of post-synaptic plasticity to investigate how schizophrenia-associated genes regulate long-term potentiation (LTP) and depression (LTD). We combined our model with data from post-mortem RNA expression studies (CommonMind ge

Studying the neural mechanisms of encoding new memories is crucial for understanding and restoring cognitive function. In this study, we utilized functional connectivity metrics to identify hubs responsible for successful or unsuccessful encoding in a free recall task among eleven epileptic patients undergoing stereo EEG presurgical evaluation. Firstly, several types of functional connectivity metrics were calculated across standard EEG bands, ripples, and fast ripples for each patient, feature, encoded word and time window across all possible pairs of contacts. Whole-brain connectivity maps w

…‘wireless’ connectivity, i.e., neuromodulation, controlling network state by way of volumetrically dispensed transmitters. What we can learn from a co

…Standard neuromodulation approaches mostly use mono- or bi-phasic pulses with varying amplitudes and intervals to deliver electrical stimulation to peripheral nerves via mono-, bi-, or tri-polar electrodes to

…research reveals its potential role in neuromodulation through its transport of various signaling molecules. Yet, to what extend CSF impacts the direct delivery of such molecules is poorly understood. CSF circulation is tightly regulated by a combination of factors such as cardiac activity, glial regulation, and notably, ciliary beating of ependymal cells lining the brain ventricles. Ciliary dysfunction, as observed in ciliopathies, ofte

…and interneurons, and are subject to neuromodulation on slower timescales in a frequency- and region-specific manner. Efferent connections, receptor densities, and neurotransmitter reuptake regulation of neuromodulatory systems are highly