Topic: chronic unpredictable mild stress

Depression is a common affective disorder that represents a heavy burden on communities. Psychobiotics, the emerging group of probiotics and postbiotics that affect brain function and mental health have shown promising results in alleviating symptoms of depression. Postbiotics, bioactive compounds released by/or produced through the metabolic activity of the microbiota, provide various beneficial effects for the host, including antidepressive ones. This study aimed to evaluate antidepressive potential of postbiotic obtained from GABA-producing B. adolescentis NGB329. We tested whether this pos

Major depressive disorder (MDD) is a widespread mental health condition affecting over 280 million people worldwide and is a major contributor to the global burden of disease. Despite selective serotonin reuptake inhibitors (SSRIs) being the first line of treatment for MDD, 30-40% of patients do not achieve remission, with chronic low-level inflammation linked to treatment resistance. This study aimed to evaluate the efficacy of the anti-inflammatory drug ibuprofen compared to the SSRI fluoxetine in a mouse model of inflamed depression. The objective was to explore whether anti-inflammatory dr

Major Depressive Disorder (MDD) is a prevalent, persistent and severe psychiatric condition characterized by persistent feelings of depression, anhedonia, and occasional suicidal thoughts, with stress identified as a major trigger. Previous research from our lab has shown changes in mouse emotional and cognitive behavior, and cellular and molecular alterations in some brain areas such as hippocampus, striatum and prefrontal cortex. Nevertheless, the mechanism underlying depression remain elusive, and so, an effective treatment. To tackle this issue, cannabidiol (CBD) treatment has emerged as a

Depression, a prevalent psychiatric disorder that significantly impacts quality of life. Cholinergic transmission dysregulation potentially contributes to emotional and behavioral disturbances. While acetylcholinesterase is commonly studied in depression, the role of butyrylcholinesterase (BChE) remains unclear. We recently developed the butyrylcholinesterase (BChE)-activatable molecular sensor (BCC) for real-time visualization of BChE activity, demonstrating its efficiency in vitro and in tumor-bearing mice. In this translational study, we employed BCC to investigate BChE changes in depressio

Depressive disorders are the leading cause of the neuropsychiatric disparity, and the lack of understanding of the causes and treatment of these disorders progresses toward therapeutic failure. Current treatment approaches only provide symptomatic relief but fail to cure the underlying pathophysiology. The present study aimed to investigate the antidepressant effect of escitalopram (ESC) and galantamine (GAL) combination in vivo on a chronic unpredictable mild stress (CUMS)-induced depression in mice and further explored its mechanism of action around cAMP, BDNF-related neurotrophic signaling,