Topic: cingulate cortex

Numerous brain pathologies are characterized by an imbalance between excitatory and inhibitory actions in brain microcircuits. The loss or loss of function of parvalbumin-positive interneurons (PV+), an interneurons subtype, is accompanied by network disturbance and cognitive dysfunction in many neuro-psychiatric diseases. Platelet-activating factor acetylhydrolase 1B subunit alpha (known as Lis1) is a regulator of dynein mediated motility, mitosis nuclear positioning and microtubule organization. Lis1 gene mutation has been associated with lissencephaly in humans and defects in neural migrati

Posttraumatic stress disorder (PTSD) manifests in some trauma-exposed individuals through excessive fear generalization to safe contexts and difficulties extinguishing fear. While previous studies have implicated functional changes in fear-regulatory nodes a comprehensive understanding of network-wide alterations remains elusive. We employed a rodent model of PTSD to investigate whole-brain activity patterns associated with fear generalization. Male rats underwent uncontrollable footshocks and 28 days later we measured their generalized fear response in an altered/safe context. Based on freezi