Topic: Circuit mapping

Postdoctoral scholarship in Prof. Jens Hjerling-Leffler's lab in the Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics. The lab studies how cell type-specific adolescent development of the nervous system influences the aetiology of psychiatric disorders, combining postmortem samples, mouse models of genetic risk, transcriptomics and large-scale human genetics of schizophrenia. The postdoc leads projects on synaptic pruning and connections during adolescence using virus-based neural circuit mapping with molecular and pharmacological tools, works with computat

Memories of emotionally-salient events are long-lasting, guiding behavior from minutes to years after learning. The prelimbic cortex (PL) is required for fear memory retrieval across time and is densely interconnected with many subcortical and cortical areas involved in recent and remote memory recall, including the temporal association area (TeA). While the behavioral expression of a memory may remain constant over time, the neural activity mediating memory-guided behavior is dynamic. In PL, different neurons underlie recent and remote memory retrieval and remote memory-encoding neurons have