Topic: cognitive function

Accumulation of heavy metals (Mn and Ni) and prolonged exposure to stress are associated with adverse health outcomes. Various studies have elucidated individually the impacts of stress and metal exposures on brain constituents and function. However, no study has examined the effects of co-exposure to stress, Mn, and Ni in the brain. This study addresses this gap by evaluating oxidative and glial responses, apoptotic activity, as well as cognitive processes in a rat model. Adult Wistar rats were exposed to vehicle (control), restraint stress, 25mg/kg of manganese (Mn) or nickel (Ni), and combi

The correlation between cognitive function, mood states, and driving behavior remains unclear. Hence, we aimed to explore this relationship objectively, by functional magnetic resonance imaging (fMRI). In a cross-sectional design, 28 male 20 to 30-year-old drivers were randomly included in the study. Each participant drove virtually in an fMRI-compatible driving simulator, after auditory and visual induction of positive, negative, and neutral mood; and fMRI was performed meanwhile to explore brain activity alterations. The analysis was performed using SPM software by performing seed-based conn