Topic: compound action potentials

Figure 1: High-frequency burst stimulation (left) triggers compound action potentials (CAP, right inset) in the medial giant fiber of the earthworm.Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are a cornerstone of modern bioelectronic interventions aiming at providing targeted therapies for various conditions such as chronic pain, epilepsy or chronic inflammation. Standard neuromodulation approaches mostly use mono- or bi-phasic pulses with varying amplitudes and intervals to deliver electrical stimulation to peripheral nerves via mono-, bi-, or tri-polar electrodes to

Oligodendrocytes (OLs) myelinate axons and are essential for fast impulse propagation and the brain’s remarkable processing power. They also carry out important homeostatic support functions that are critical for maintaining long-term neuronal integrity. Mitochondrial reactive oxygen species (ROS) are implicated in various neurodegenerative diseases and influence cell functions in a cell-specific manner, yet the (patho)physiological impact of oligodendroglial ROS on neural functions remains unknown. To study the impact of oligodendroglial ROS in aging and disease, we generated mice (termed OL-