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Radiopharmaceutical evaluation of novel bifunctional chelators and bioconjugates for tumour imaging and therapy
Bispidines (3,7-diazabicyclo[3.3.1]nonane) and their derivatives act as bifunctional chelators (BFC), combining the advantages of multidentate macrocyclic and acyclic ligands e.g. high kinetic inertness, rapid radiolabelling under mild conditions. This bicyclic chelator system shows a great diversity in terms of its denticity and type of functional groups, yielding a wide range of multidentate ligands that can bind a variety of different metal ions. In addition, they allow a facile functionalisation of targeting molecules such as peptides, peptidomimetics, and bispecic antibodies. Herein, examples of various bispidine complexes labelled with [64Cu]Cu2+, [111In]In3+, [ 177Lu]Lu3+ or [ 225Ac]Ac3+ will be presented which provide a picture of how different substituents inuence the coordination mode. Target-specic radiolabelled bispidine-based conjugates (e.g. peptides, antibody fragments, antibodies) investigated in vivo by positron emission or single-photon emission computed tomography will be presented and discussed in terms of their suitability for nuclear medicine applications.
Internal structure of honey bee swarms for mechanical stability and division of labor
The western honey bee (Apis mellifera) is a domesticated pollinator famous for living in highly social colonies. In the spring, thousands of worker bees and a queen fly from their hive in search of a new home. They self-assemble into a swarm that hangs from a tree branch for several days. We reconstruct the non-isotropic arrangement of worker bees inside swarms made up of 3000 - 8000 bees using x-ray computed tomography. Some bees are stationary and hang from the attachment board or link their bodies into hanging chains to support the swarm structure. The remaining bees use the chains as pathways to walk around the swarm, potentially to feed the queen or communicate with one another. The top layers of bees bear more weight per bee than the remainder of the swarm, suggesting that bees are optimizing for additional factors besides weight distribution. Despite not having a clear leader, honey bees are able to organize into a swarm that protects the queen and remains stable until scout bees locate a new hive.
Virtual launch and webinar: Magnetic Particle Imaging at Monash University
Magnetic Particle Imaging (MPI) is a new non-invasive imaging technique with significantly increased sensitivity over MRI and faster acquisition times than PET and MRI. The MPI capability at the Alfred Research Alliance - Monash Biomedical Imaging site in Melbourne, Australia, is the world’s first MPI system with Computed Tomography (CT) and Hyperthermia capabilities. It provides unique capabilities that open the door to cutting-edge opportunities for interdisciplinary projects in medical research, chemistry and biotechnology. The webinar will involve: * official launch of Magnetic Particle Imaging at Monash University * the MPI system supplier, Magnetic Insight, discussing the world first technology and its potential * presentations from key researchers outlining MPI applications and the benefits of utilising the technology.